Nondisjunction true statements
  • Homologs separate during meiosis IOne diploid cell produces 4 haploid cells Sister chromatids separate from each other during meiosis IINOT: 2 haploid gametes fuse to form a diploid cell
  • 2 products of the second meiotic division have both the maternal and paternal chromosomes of a set and the other 2 products have none for that setNondisjunction during meiosis I yields two gametes that are missing a particular chromosome after meiosis II.
  • Homologs fail to separate during meiosis IOrdinarily, homologs separate during meiosis I. Failure of this separation is one of the ways which nondisjunction occurs
  • It occurs more frequently in human females over the age of 35It may fail to separate maternal from paternal chromosomesIt may fail to separate maternal chromatids from one another and paternal chromatids from one another
The incidence of Down syndrome, also known as trisomy 21, increases with increasing maternal age. Which of the following errors most likely produces this condition?
  • 2 products of the second meiotic division have both the maternal and paternal chromosomes of a set and the other 2 products have none for that setNondisjunction during meiosis I yields two gametes that are missing a particular chromosome after meiosis II.
  • aneuploidy
  • Homologs fail to separate during meiosis IOrdinarily, homologs separate during meiosis I. Failure of this separation is one of the ways which nondisjunction occurs
  • Nondisjunction during either meiosis I or II in female gameteNondisjunction during either meiosis I or II can produce a gamete that will result in a trisomic zygote. Since the incidence of Down syndrome increases with maternal age, it is likely that this error occurs in the female gamete.
Which of the following accurately describes a possible meiotic nondisjunction event?
  • Homologs fail to separate during meiosis IOrdinarily, homologs separate during meiosis I. Failure of this separation is one of the ways which nondisjunction occurs
  • 2 products of the second meiotic division have both the maternal and paternal chromosomes of a set and the other 2 products have none for that setNondisjunction during meiosis I yields two gametes that are missing a particular chromosome after meiosis II.
  • Homologs separate during meiosis IOne diploid cell produces 4 haploid cells Sister chromatids separate from each other during meiosis IINOT: 2 haploid gametes fuse to form a diploid cell
  • Nondisjunction during either meiosis I or II in female gameteNondisjunction during either meiosis I or II can produce a gamete that will result in a trisomic zygote. Since the incidence of Down syndrome increases with maternal age, it is likely that this error occurs in the female gamete.
Which of the following statements about the products produced when nondisjunction occurs during meiosis I is true?
  • Nondisjunction during either meiosis I or II in female gameteNondisjunction during either meiosis I or II can produce a gamete that will result in a trisomic zygote. Since the incidence of Down syndrome increases with maternal age, it is likely that this error occurs in the female gamete.
  • 2 products of the second meiotic division have both the maternal and paternal chromosomes of a set and the other 2 products have none for that setNondisjunction during meiosis I yields two gametes that are missing a particular chromosome after meiosis II.
  • Homologs fail to separate during meiosis IOrdinarily, homologs separate during meiosis I. Failure of this separation is one of the ways which nondisjunction occurs
  • It occurs more frequently in human females over the age of 35It may fail to separate maternal from paternal chromosomesIt may fail to separate maternal chromatids from one another and paternal chromatids from one another
Events during normal meisois
  • 2 products of the second meiotic division have both the maternal and paternal chromosomes of a set and the other 2 products have none for that setNondisjunction during meiosis I yields two gametes that are missing a particular chromosome after meiosis II.
  • Homologs separate during meiosis IOne diploid cell produces 4 haploid cells Sister chromatids separate from each other during meiosis IINOT: 2 haploid gametes fuse to form a diploid cell
  • Homologs fail to separate during meiosis IOrdinarily, homologs separate during meiosis I. Failure of this separation is one of the ways which nondisjunction occurs
  • It occurs more frequently in human females over the age of 35It may fail to separate maternal from paternal chromosomesIt may fail to separate maternal chromatids from one another and paternal chromatids from one another
True or false? Nondisjunction is viewed as a major case of aneuploidy.
  • True
  • False
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