Which protein has been produced generating a transgenic sheep that is used for replacement therapy for individuals at risk from emphysema?
Plasminogen activator (rPA)
α-antitrypsin (ATT)
Casein
Amyloid precursor proteins
A genetically engineered micro-organism used successfully in bioremediation of oil spills is a species of:
Pseudomonas
Trichoderma
Xanthomonas
Bacillus
Which kind of therapy was given in 1990 to a four-year-old girl with Adenosine Deaminase (ADA) deficiency ?
Gene therapy
Chemotherapy
Immunotherapy
Radiation therapy
The two polypeptides of human insulin are linked together by
phosphodiester bonds
covalent bonds
disulphide bridges
hydrogen bonds
Which part of the tobacco plant is infected by Meloidegyne incognitia?
Leaf
Stem
Root
Flower
Golden rice is a genetically modified crop plant where the incorporated gene is meant for
biosynthesis of
vitamin-B
omega 3
vitamin-C
vitamin-A
In Bt cotton, the Bt toxin present in plant tissue as pro-toxin is converted into active toxin due to
Alkaline pH of the insect gut
acidic pH of the insect gut
action of gut microorganisms
presence of conversion factors in insect gut
A single strand of nucleic acid tagged with a radioactive molecule is called
vector
selectable marker
plasmid
probe
The process of RNA interference has been used in the development of plants resistant to
fungi
viruses
insects
nematodes
Maximum number of existing transgenic animals is of
mice
cow
pig
fish
The tobacco plant has been made resistant to the tobacco mosaic virus by:
introducing T -DNA of Agrobacterium
introducing a gene for vims coat protein
introducing meristematic activity in somatic cells
applying newer generation pesticides to the crops
Plants are more easily manipulated by genetic engineering than are animals because:
Plant genes do not contain introns
More vectors are available to transfer rDNA into plant cells
Totipotency is a feature generally associated with plant cells and not with animal cells
Genes can be inserted into animal cells by microinjection.
Identify the incorrectly matched pair :
1.
Humulin
First therapeutic rDNA product approved for human use
2.
RNAi
Silencing of mRNA with the help of dsRNA
3.
Rosie
Transgenic sheep producing alpha 1 antitrypsin
4.
Golden rice
Vitamin A enriched rice variety
RNAi is a mechanism to silence genes with the help of
ssRNA
dsRNA
ssDNA
dsDNA
To protect tobacco plants against Meloidegyne incognita using RNAi, nematode specific genes were introduced in the plant using:
Transposons
Retrotransposons
Virus with RNA genome
Agrobacterium
A permanent cure for ADA deficiency could be:
Enzyme replacement therapy
Bone marrow transplant
Introduction of a functional ADA cDNA into lymphocytes
Introduction of gene isolate from marrow cells producing ADA into early embryonic cells
Polymerase Chain Reaction is not used in :
Confirming presence of a pathogen during early infection
Identifying the mutated genes in suspected cancer patients
Isolating the gene of interest from host DNA to be cloned by recombinant procedures
Detection of the presence of HIV in suspected AIDS patient
If gene isolate from marrow cells producing ADA is introduced into cells at early embryonic stage, it could be a permanant cure of ADA deficiency because the early embryonic cells :
Are more differentiated than the later stage cells
Are constantly dividing and do not get differentiated
Are easy to manipulate than the later stage cells
Are virtually immortal
To test the safety of polio vaccine, the organisms used are transgenic :
Mice
Pigs
Monkey
Cattle
If the goal were to create a plant resistant to an insecticide, which cell-based plant technology would be most effective ?
clonal propagation
cybridization
protoplast fusion
mutant selection
The genetically-modified (GM) brinjal in India has been developed for
insect-resistant
enhancing self life
enhancing mineral content
drought-resistance
DNA or RNA segment tagged with a radioactive molecule is called
clone
Genetic engineering has been successfully used for producing
transgenic mice for testing safety of polio vaccine before use in humans
transgenic models for studying new treatments for certain cardiac diseases
Transgenic cow-Rosie which produces high fat milk for making ghee
animals like bulls for farm work as they have super power
Some of the characteristics of Bt cotton are
long fibre and resistance to aphids
medium yields, long fibres and resistance to beetle pests
high yield and production of toxic protein crystals which kill dipteran pests
high yield and resistance to bollworms
An improved variety of transgenic basmati rice
does not require chemical fertilizers and growth hormones
gives high yield and is rich in vitamin-A
is completely resistant to all insect pests and diseases of paddy
gives high yield but has no characteristic aroma
The bacterium Bacillus thuringiensis is widely used in contemporary biology as a/an
indicator of water pollution
insecticide
agent for production of dairy products
source of industrial enzyme
The genetic defect-Adenosine Deaminase (ADA) deficiency may be cured permanently by
periodic infusion of genetically engineered lymphocytes having functional ADA cDNA
administering adenosine deaminase activators
introducing bone marrow genes producing ADA into cells at early embryonic stages
enzyme replacement therapy
What is true about Bt toxin?
multiplication
The inactive protoxin gets converted into active form in the insect gut
Bt protein exists as active toxin in the Bacillus
The activated toxin enters the ovaries of the pest to sterilize it and thus prevent its
The concerned Bacillus has antitoxins
A transgenic food crop, which may help in solving the problem of night blindness in developing countries is:
Flavr savr tomatoes
Starlink maize
Bt soybean
Main objective of production / use of herbicide resistant GM crops is to
eliminate weeds from the field without the use of manual labour
eliminate weeds from the field without the use of herbicides
encourage eco-friendly herbicides
reduce herbicide accumulation in food particles for health safety
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