Select the two statements out of the four (A - D) given below about lac operon.
(A) Glucose or galactose may bind with the repressor and inactivate it
(B) In the absence of lactose, the repressor binds with the operator region
(C) The z-gene codes for permease
(D) This was elucidated by Francois Jacob and Jacques Monod
The correct statements are
(B) and (C)
(A) and (C)
(B) and (D)
(A) and (B)
The one aspect which is not a salient feature of genetic code, is its being
degenerate
ambiguous
universal
specific
Satellite DNA is useful tool in
organ transplantation
sex determination
forensic science
genetic engineering
Which one of the following does not follow the central dogma of molecular biology?
Pea
Mucor
Chlamydomonas
HIV
Whose experiments cracked the DNA and discovered unequivocally that a genetic code is a triplet?
Nirenberg and Mathaei
Hershey and chase
Morgan and Sturtevant
Beadle and Tatum
Semi-conservative replication of DNA was first demonstrated in
Drosophila melanogaster
Escherichia coli
Streptococcus pneumoniae
Salmonella typhimurium
What is not true for genetic code?
A codon in mRNA is read in a non-contiguous fashion
It is nearly universal
It is degenerate
It is unambiguous
In the DNA molecule
the total amount of purine nucleotides and pyrimidine nucleotides is not always equal
there are two strands, which run parallel in the 5’ → 3’direction
the proportion of adenine in relation to thymine varies with the organism
there are two strands, which run antiparallel-one in 5’ → 3’ direction and other in 3’ → 5’
Which one of the following pairs of codons are correctly matched with their function or the signal for the particular amino acid?
GUU, GCU – Alanine
UAG, UGA – Stop
AUG, ACG – Start/methionine
UUA, UCA – Leucine
Haploids are more suitable for mutation studies than the diploids. This is because
haploids are reproductively more stable than diploids
mutagenes penetrate in haploids more effectively than is diploids
haploids are more abundant in nature than diploids
all mutations, whether dominant or recessive are expressed in haploids
Telomere repetitive DNA sequences control the function of eukaryotic chromosomes because they:
act as replicons
are RNA transcription initiator
help chromosome pairing
prevent chromosome loss
Molecular basis of organ differentiation depends on the modulation in transcription by:
RNA polymerase
ribosome
transcription factor
anticodon
The length of DNA molecule greatly exceeds the dimensions of the nucleus in eukaryotic cells. How is this DNA accommodated?
Deletion of non essential genes
Super-coiling in nucleosomes
DNAse digestion
Through elimination of repetitive DNA
During transcription RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure. What is it’s DNA-binding sequence?
TTAA
AATT
CACC
TATA
Differentiation of organs and tissues in a developing organism, is associated with:
developmental mutations
differential expression of genes
lethal mutations
deletion of gens
The Okazaki fragments in DNA chain growth:
result in transcription
polymerize in the 3’-to-5’ direction and forms replication fork
prove semi-conservative nature of DNA replication
polymerize in the 5’-to-3’ direction and explain 3’-to-5’ DNA replication
The two polynucleotide chains in DNA are:
parallel
discontinuous
antiparallel
semiconservative
One gene-one enzyme relationship was established for the first time in:
Neurospora crassa
Diplococcus pneumoniae
A sequential expression of a set of human genes occurs when a steroid molecule binds to
the:
transfer RNA
messenger RNA
DNA sequence
Which antibiotic inhibits interaction between t-RNA and m-RNA during bacterial protein synthesis?
Erythromycin
Penicillin
Streptomycin
Tetracycline
Amino acid sequence, in protein synthesis is decided by the sequence of
t-RNA
m-RNA
c-DNA
r-RNA
One gene-one enzyme hypothesis was postulated by:
R. Franklin
Hershey and Chase
A. Garrod
One turn of the helix in a B-form DNA is approximately:
20 nm
0.34 nm
3.4 nm
2 nm
Antiparallel strands of a DNA molecule means that:
one strand turns anti-clockwise
the phosphate groups of two DNA strands, at their ends, share the same position
the phosphate groups at the start of two DNA strands are in opposite position (pole)
one strand turns clockwise
Complete genomic sequence of the following plant has been recently announced is
Arabidopsis thaliana
Tritium vulgare
Cucurbita pepo
Pisum sativum
Okazaki fragments are proportions of DNA
synthesized on the leading strand of DNA replication fork
synthesized on the lagging strand of DNA replication fork
produced during the digestion of DNA by restriction endonucleases
none of the above
Transcription in case of eukaryotes takes place in
nucleus
nucleolus
cytoplasm
Which of the following banding group is used in staining both plant and animal chromosome?
C-group
G-group
R-group
N-group
Which of the following is nonsense codon?
UAG
UAA
UGA
all the above
Frameshift mutation occurs when
base is subsituted
base is deleted or added
anticodons are absent
none of these
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