Wobble hypothesis was given by

  • R.W. Holley

  • M. Nirenberg

  • H.G. Khorana

  • F.H.C. Crick

Which one of the following pairs of terms / names mean one and the same thing?

 

  • Gene pool - genome

  • Codon – gene

  • Cistron – triplet

  • DNA fingerprinting - DNA profiling

What is true about tRNA?

  • It binds with an amino acid at it 3’ end

  • It has five double stranded regions

  • It has a codon at one end which recognizes the anticodon on messenger RNA

  • It looks like clover leaf in the three dimensional structure.

Which one of the following correctly represents the manner of replication of DNA?

 

Which one of the following codons codes for the same information as UGC?

  • UGU

  • UGA

  • UAG

  • UGG

The total number of nitrogenous bases in human genome is estimated to be about

  • 3.5 million

  • 35 thousand

  • 35 million

  • 3.1 billion

What is the first step in the Southern Blot technique?

  • Denaturation of DNA on the gel for hybridization with specific probe

  • Production of a group of genetically identical cells

  • Digestion of DNA by restriction enzyme

  • Isolation of DNA from a nucleated cell such as the one from the scene of crime

Given below is a representation of a kind of chromosomal mutation. What is the kind of mutation represented?

  • Deletion

  • Duplication

  • Inversion

  • Reciprocal translocation

Which one of the following pairs is correctly matched with regard to the codon and the amino acid coded by it?

  • UUA - valine

  • AAA - lysine

  • AUG - cysteine

  • CCC - alanine

Some of the steps of DNA fingerprinting are given below. Identify their correct sequence from the options given.

A. Electrophoresis of DNA fragments

B. Hybridisation with DNA probe

C. Digestion of DNA by restriction endonucleases

D. Autoradiography

E. Blotting of NDA fragments to nitrocellulose membrane

  • C – A – B – E – D

  • C – A – E – B – D

  • A – E – C – B – D

  • A – C – E – D – B

If the sequence of bases in the coding strand of a double stranded DNA is 5’-GTTCGAGTC-3’, the sequence of bases in its transcript will be

  • 5’-GACUCGAAC-3’

  • 5’-CAAGCUCAG-3’

  • 5’-GUUCGAGUC-3’

  • 5’-CUGAGCUUG-3’

Refer to the given figure and select the correct option regarding its parts labelled as A, B and C.

  • A-Histone octamer, C-DNA

  • B-H1 histone, C-Histone octamer

  • A-H1 histone, B-DNA

  • A-Histone octamer, C-H1 histone

Match the triplet codons listed in column I with their amino acids mentioned in column II and select the correct option from the given codes.

  Column I

   Column II

A. GGG

(i) Proline

B. UUU

(ii) Glycine

C. CCC

(iii) Arginine

D. AAA

(iv) Phenylalanine

 

(v) Lysine

  • A-(v), B-(iii), C-(i), D-(ii)

  • A-(v), B-(iii), C-(i), D-(iv)

  • A-(ii), B-(iv), C-(i), D-(v)

  • A-(i), B-(ii), C-(iii), D-(iv)

Match the following column

Column I

Column II

I. Multigenes

(i) transposons

II. Inducible genes

(ii) insulin

III. Overlapping genes

(iii) B, E and k in ϕ × 174

IV. Structural genes

(iv) snRNA

 

(v) globin gene

 

(vi) nitrate reductase

 

I

II

III

IV

(1)

(i)

(iii)

(v)

(ii)

(2)

(v)

(vi)

(iii)

(ii)

(3)

(iv)

(v)

(vi)

(i)

(4)

(i)

(ii)

(v)

(vi)

 
  • 1
  • 2
  • 3
  • 4

The premature termination of polypeptide synthesis due to stop codon can be overcome via compensatory mutation in tRNA. This genetic phenomenon is called

  • extragenic suppression

  • intragenic suppression

  • codon bias

  • true reversion

Suppose, evolution on earth had occurred in such a way that there are 96 amino acids instead of 20. DNA has 12 different types of bases and DNA synthesis occurs in the same way as today. The minimum number of bases per DNA codon would be

  • 12

  • 8

  • 2

  • 3

Radioactive thymidene is fed to cells about to enter S-phase. It will make radioactive

  • euchromatin

  • heterochromatin

  • Both (1) and (2)

  • neither euchromatin nor heterochromatin

What would happen, if in a gene encoding a polypeptide of 50 amino acids, 25th codon (UAU) is mutated to UAA?

  • A polypeptide of 49 amino acids will be formed

  • A polypeptide of 25 amino acids will be formed

  • A polypeptide of 24 amino acids will be formed

  • Two polypeptides of 24 and 25 amino acids will be formed

Which one of the following set meaning is not different?

–

Triplet

–

DNA type

–

Genome

–

Codon

 

  • Cistron

  • DNA profile

  • Gene pool

  • Gene

Okazaki is known for his contribution to the understanding of

  • transcription

  • translation

  • DNA replication

  • mutation

The beginning of understanding genetic transformation in bacteria was made by

  • Frederick Griffith

  • Hershey and Chase

  • Watson and Crick

  • TH Morgan

If the total amount of adenine and thymine in a double-stranded DNA is 45%, the amount of guanine in this DNA will be

  • 22.5%

  • 27.5%

  • 45%

  • 55%

AUG codes for

  • valine

  • histidine

  • phenylalanine

  • methionine

In the lac operon model, lactose molecules function as:-
gne
gene
protein
protein
  • inducers, which bind with the operator
  • repressors, which bind with the operator
  • inducers, which bind with the repressor
  • corepressors, which bind with repressors

A recessive mutant is one which is

  • not expressed

  • rarely expressed

  • expressed only in homozygous and hemizygous state

  • expressed only in heterozygous state

If the total amount of adenine and thymine in a double-stranded DNA is 60%, the amount of guanine in this DNA will be

  • 15%

  • 20%

  • 30%

  • 40%

If T = 40%, C = 10% then G = ? in a pollen cell

  • 40%

  • 10%

  • 91%

  • 20%

Translocase is an enzyme required for

  • DNA replication

  • RNA synthesis

  • initiation of protein synthesis

  • protein synthesis chain elongation

Centre of DNA Fingerprinting and Diagnostics (CDFD) is located at

  • Delhi

  • Chennai

  • Kolkata

  • Hyderabad

In a bacterium, the amount of adenine was found to be 18 per cent. Suggest the cytosine base composition from the following

  • 64%

  • 36%

  • 32%

  • 18%

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